Chen, Bin Lin

Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Rα-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice. [electronic resource] - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 11 2018 - 1494-1508 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1365-2222

10.1111/cea.13258 doi


Allergens--immunology
Animals
Asthma--drug therapy
Biomarkers
Curcumin--analogs & derivatives
Cytokines--metabolism
Disease Models, Animal
Female
Inflammation Mediators--metabolism
Jagged-1 Protein--metabolism
Jagged-2 Protein--metabolism
Janus Kinase 1--metabolism
Leukocytes--immunology
Mice
Oxidative Stress
Receptor, Notch1--metabolism
Receptor, Notch2--metabolism
Receptors, Cell Surface--metabolism
STAT6 Transcription Factor--metabolism
Signal Transduction--drug effects
Th2 Cells--immunology