TY  - GEN
AU  - Takada,Marilia
AU  - Hix,Jeremy M L
AU  - Corner,Sarah
AU  - Schall,Peter Z
AU  - Kiupel,Matti
AU  - Yuzbasiyan-Gurkan,Vilma
TI  - Targeting MEK in a Translational Model of Histiocytic Sarcoma
SN  - 1538-8514
PY  - 2019///0910
KW  - Animals
KW  - Apoptosis
KW  - drug effects
KW  - Cell Cycle
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - Dogs
KW  - Down-Regulation
KW  - Female
KW  - Histiocytic Sarcoma
KW  - drug therapy
KW  - Liver
KW  - MAP Kinase Signaling System
KW  - Mice, Inbred NOD
KW  - Mice, SCID
KW  - Mitogen-Activated Protein Kinase Kinases
KW  - antagonists & inhibitors
KW  - Models, Biological
KW  - Molecular Targeted Therapy
KW  - Phosphatidylinositol 3-Kinases
KW  - metabolism
KW  - Proto-Oncogene Proteins c-akt
KW  - Pyridones
KW  - pharmacology
KW  - Pyrimidinones
KW  - Survival Analysis
KW  - Translational Research, Biomedical
KW  - Up-Regulation
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1158/1535-7163.MCT-17-1273
ER  -