TY  - GEN
AU  - Fensome,Andrew
AU  - Ambler,Catherine M
AU  - Arnold,Eric
AU  - Banker,Mary Ellen
AU  - Brown,Matthew F
AU  - Chrencik,Jill
AU  - Clark,James D
AU  - Dowty,Martin E
AU  - Efremov,Ivan V
AU  - Flick,Andrew
AU  - Gerstenberger,Brian S
AU  - Gopalsamy,Ariamala
AU  - Hayward,Matthew M
AU  - Hegen,Martin
AU  - Hollingshead,Brett D
AU  - Jussif,Jason
AU  - Knafels,John D
AU  - Limburg,David C
AU  - Lin,David
AU  - Lin,Tsung H
AU  - Pierce,Betsy S
AU  - Saiah,Eddine
AU  - Sharma,Raman
AU  - Symanowicz,Peter T
AU  - Telliez,Jean-Baptiste
AU  - Trujillo,John I
AU  - Vajdos,Felix F
AU  - Vincent,Fabien
AU  - Wan,Zhao-Kui
AU  - Xing,Li
AU  - Yang,Xiaojing
AU  - Yang,Xin
AU  - Zhang,Liying
TI  - Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)
SN  - 1520-4804
PY  - 2019///1007
KW  - Animals
KW  - Antitubercular Agents
KW  - pharmacology
KW  - Arthritis, Experimental
KW  - chemically induced
KW  - Female
KW  - Janus Kinase 1
KW  - antagonists & inhibitors
KW  - Molecular Structure
KW  - Mycobacterium tuberculosis
KW  - drug effects
KW  - Protein Kinase Inhibitors
KW  - Pyrazoles
KW  - Pyrimidines
KW  - Rats
KW  - Rats, Inbred Lew
KW  - TYK2 Kinase
KW  - Tuberculosis
KW  - complications
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1021/acs.jmedchem.8b00917
ER  -