TY - GEN AU - Logue,Susan E AU - McGrath,Eoghan P AU - Cleary,Patricia AU - Greene,Stephanie AU - Mnich,Katarzyna AU - Almanza,Aitor AU - Chevet,Eric AU - Dwyer,Róisín M AU - Oommen,Anup AU - Legembre,Patrick AU - Godey,Florence AU - Madden,Emma C AU - Leuzzi,Brian AU - Obacz,Joanna AU - Zeng,Qingping AU - Patterson,John B AU - Jäger,Richard AU - Gorman,Adrienne M AU - Samali,Afshin TI - Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy SN - 2041-1723 PY - 2019///0102 KW - Animals KW - Antineoplastic Combined Chemotherapy Protocols KW - pharmacology KW - Cell Line KW - Cell Line, Tumor KW - Endoribonucleases KW - antagonists & inhibitors KW - Enzyme Inhibitors KW - administration & dosage KW - Female KW - Gene Expression Profiling KW - Gene Expression Regulation, Neoplastic KW - HEK293 Cells KW - Humans KW - Mice, Nude KW - Paclitaxel KW - Protein Serine-Threonine Kinases KW - RNA Interference KW - Triple Negative Breast Neoplasms KW - drug therapy KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/s41467-018-05763-8 ER -