TY  - GEN
AU  - Nichols,Robert J
AU  - Haderk,Franziska
AU  - Stahlhut,Carlos
AU  - Schulze,Christopher J
AU  - Hemmati,Golzar
AU  - Wildes,David
AU  - Tzitzilonis,Christos
AU  - Mordec,Kasia
AU  - Marquez,Abby
AU  - Romero,Jason
AU  - Hsieh,Tientien
AU  - Zaman,Aubhishek
AU  - Olivas,Victor
AU  - McCoach,Caroline
AU  - Blakely,Collin M
AU  - Wang,Zhengping
AU  - Kiss,Gert
AU  - Koltun,Elena S
AU  - Gill,Adrian L
AU  - Singh,Mallika
AU  - Goldsmith,Mark A
AU  - Smith,Jacqueline A M
AU  - Bivona,Trever G
TI  - RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers
SN  - 1476-4679
PY  - 2019///0507
KW  - Animals
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Biomarkers, Tumor
KW  - genetics
KW  - Cell Line, Tumor
KW  - Enzyme Inhibitors
KW  - Extracellular Signal-Regulated MAP Kinases
KW  - metabolism
KW  - Genetic Predisposition to Disease
KW  - Guanosine Triphosphate
KW  - HEK293 Cells
KW  - Humans
KW  - Mice, Inbred BALB C
KW  - Mice, Nude
KW  - Mitogen-Activated Protein Kinase Kinases
KW  - Mutation
KW  - Neoplasms
KW  - drug therapy
KW  - Neurofibromin 1
KW  - Phenotype
KW  - Protein Tyrosine Phosphatase, Non-Receptor Type 11
KW  - antagonists & inhibitors
KW  - Proto-Oncogene Proteins B-raf
KW  - Proto-Oncogene Proteins p21(ras)
KW  - SOS1 Protein
KW  - Signal Transduction
KW  - Tumor Burden
KW  - drug effects
KW  - Xenograft Model Antitumor Assays
KW  - raf Kinases
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41556-018-0169-1
ER  -