Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP). [electronic resource]
- Science translational medicine 08 2018
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1946-6242
10.1126/scitranslmed.aan0941 doi
Animals Antineoplastic Combined Chemotherapy Protocols--pharmacology Bortezomib--pharmacology Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p21--genetics DNA Damage DNA Methylation--genetics Decitabine--pharmacology Dose-Response Relationship, Drug Drug Resistance, Neoplasm--drug effects Drug Synergism Gene Expression Regulation, Neoplastic--drug effects Genes, Tumor Suppressor High-Throughput Screening Assays Humans Mice Mitomycin--pharmacology Multiple Myeloma--drug therapy Phenotype Protein Tyrosine Phosphatase, Non-Receptor Type 6--genetics RNA, Messenger--genetics Tumor Burden--drug effects