Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERĪ± [electronic resource]
- Cancer discovery 09 2018
- 1176-1193 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2159-8290
10.1158/2159-8290.CD-17-1229 doi
Administration, Oral Animals Breast Neoplasms--drug therapy Cell Line, Tumor Cell Proliferation--drug effects Cell Survival--drug effects Cysteine--antagonists & inhibitors Drug Resistance, Neoplasm--drug effects Drug Screening Assays, Antitumor Drug Synergism Estrogen Receptor Antagonists--administration & dosage Estrogen Receptor alpha--antagonists & inhibitors Female Humans Indazoles--administration & dosage MCF-7 Cells Mice Mutation Protein Conformation--drug effects Protein Kinase Inhibitors--administration & dosage Xenograft Model Antitumor Assays