Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway. [electronic resource]
- Science signaling 07 2018
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1937-9145
10.1126/scisignal.aar5401 doi
Active Transport, Cell Nucleus Adult Aged, 80 and over Case-Control Studies Cell Nucleus--metabolism Cells, Cultured Cellular Senescence Child Female Fibroblasts--metabolism Humans Male Microtubules--metabolism N-Terminal Acetyltransferase E--antagonists & inhibitors N-Terminal Acetyltransferases Nuclear Pore Complex Proteins--genetics Phenotype Progeria--genetics Proto-Oncogene Proteins--genetics Young Adult beta Karyopherins--genetics ran GTP-Binding Protein--genetics