TY - GEN AU - Ressa,Anna AU - Bosdriesz,Evert AU - de Ligt,Joep AU - Mainardi,Sara AU - Maddalo,Gianluca AU - Prahallad,Anirudh AU - Jager,Myrthe AU - de la Fonteijne,Lisanne AU - Fitzpatrick,Martin AU - Groten,Stijn AU - Altelaar,A F Maarten AU - Bernards,René AU - Cuppen,Edwin AU - Wessels,Lodewyk AU - Heck,Albert J R TI - A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells SN - 1535-9484 PY - 2019///0506 KW - Cell Cycle KW - drug effects KW - Cell Line, Tumor KW - Cell Proliferation KW - Colorectal Neoplasms KW - genetics KW - Down-Regulation KW - Drug Synergism KW - ErbB Receptors KW - antagonists & inhibitors KW - Feedback, Physiological KW - Gene Expression Regulation, Neoplastic KW - Gene Knockout Techniques KW - Humans KW - MAP Kinase Signaling System KW - Models, Biological KW - Mutation KW - Phosphatidylinositol 3-Kinases KW - metabolism KW - Protein Kinase Inhibitors KW - pharmacology KW - Protein Tyrosine Phosphatase, Non-Receptor Type 11 KW - Proto-Oncogene Proteins B-raf KW - Proto-Oncogene Proteins c-akt KW - Systems Biology KW - methods N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1074/mcp.RA117.000486 ER -