Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas. [electronic resource]
- Science translational medicine 06 2018
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1946-6242
10.1126/scitranslmed.aar7223 doi
Active Transport, Cell Nucleus--drug effects Animals Anthracyclines--pharmacology Cell Line, Tumor Cell Nucleus--drug effects Doxorubicin--pharmacology Drug Resistance, Neoplasm--drug effects E2F1 Transcription Factor--metabolism E2F7 Transcription Factor--metabolism Humans Karyopherins--antagonists & inhibitors Mice, Inbred NOD Mice, SCID Molecular Targeted Therapy Phosphotransferases (Alcohol Group Acceptor)--metabolism Receptors, Cytoplasmic and Nuclear--antagonists & inhibitors Squamous Cell Carcinoma of Head and Neck--metabolism Exportin 1 Protein