Depletion of A-type lamins and Lap2α reduces 53BP1 accumulation at UV-induced DNA lesions and Lap2α protein is responsible for compactness of irradiated chromatin. [electronic resource]
- Journal of cellular biochemistry 11 2018
- 8146-8162 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1097-4644
10.1002/jcb.26770 doi
Animals Cell Line, Transformed Chromatin--chemistry DNA Damage DNA Repair DNA-Binding Proteins--deficiency Embryo, Mammalian Fibroblasts--cytology Fluorescence Recovery After Photobleaching Gamma Rays Gene Expression Regulation Genes, Reporter Histones--genetics Lamin Type A--deficiency Luminescent Proteins--genetics Membrane Proteins--deficiency Mice Recombinant Fusion Proteins--genetics Signal Transduction Tumor Suppressor p53-Binding Protein 1--genetics Ultraviolet Rays Red Fluorescent Protein