TY - GEN AU - Vinogradova,Tatiana M AU - Sirenko,Syevda AU - Lukyanenko,Yevgeniya O AU - Yang,Dongmei AU - Tarasov,Kirill V AU - Lyashkov,Alexey E AU - Varghese,Nevin J AU - Li,Yue AU - Chakir,Khalid AU - Ziman,Bruce AU - Lakatta,Edward G TI - Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4 SN - 1941-3084 PY - 2019///0813 KW - Action Potentials KW - drug effects KW - Animals KW - Biological Clocks KW - Calcium Signaling KW - Cyclic AMP KW - metabolism KW - Cyclic AMP-Dependent Protein Kinases KW - Cyclic Nucleotide Phosphodiesterases, Type 3 KW - genetics KW - Cyclic Nucleotide Phosphodiesterases, Type 4 KW - Enzyme Activation KW - Heart Rate KW - Kinetics KW - Phosphodiesterase 3 Inhibitors KW - pharmacology KW - Phosphodiesterase 4 Inhibitors KW - Rabbits KW - Ryanodine Receptor Calcium Release Channel KW - Sinoatrial Node KW - cytology N1 - Publication Type: Journal Article; Research Support, N.I.H., Intramural UR - https://doi.org/10.1161/CIRCEP.117.005896 ER -