TY - GEN AU - Gunaratne,Ruwan AU - Kumar,Shekhar AU - Frederiksen,James W AU - Stayrook,Steven AU - Lohrmann,Jens L AU - Perry,Kay AU - Bompiani,Kristin M AU - Chabata,Charlene V AU - Thalji,Nabil K AU - Ho,Michelle D AU - Arepally,Gowthami AU - Camire,Rodney M AU - Krishnaswamy,Sriram AU - Sullenger,Bruce A TI - Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass SN - 1546-1696 PY - 2018///1226 KW - Anticoagulants KW - administration & dosage KW - Aptamers, Nucleotide KW - Cardiopulmonary Bypass KW - adverse effects KW - Crystallography, X-Ray KW - Drug Combinations KW - Factor Xa KW - chemistry KW - Factor Xa Inhibitors KW - Heparin KW - Humans KW - Postoperative Hemorrhage KW - drug therapy KW - Protein Conformation KW - drug effects N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S UR - https://doi.org/10.1038/nbt.4153 ER -