TY - GEN AU - Fraser,C M AU - Chung,F Z AU - Wang,C D AU - Venter,J C TI - Site-directed mutagenesis of human beta-adrenergic receptors: substitution of aspartic acid-130 by asparagine produces a receptor with high-affinity agonist binding that is uncoupled from adenylate cyclase SN - 0027-8424 PY - 1988///0907 KW - Adenylyl Cyclases KW - metabolism KW - Animals KW - Asparagine KW - genetics KW - Aspartic Acid KW - Base Sequence KW - Binding, Competitive KW - Catecholamines KW - Cell Line KW - Gene Expression Regulation KW - Guanine Nucleotides KW - pharmacology KW - Humans KW - Molecular Sequence Data KW - Mutation KW - Receptors, Adrenergic, beta KW - Sequence Homology, Nucleic Acid N1 - Publication Type: Journal Article UR - https://doi.org/10.1073/pnas.85.15.5478 ER -