Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor. [electronic resource]
- Cell death & disease 04 2018
- 613 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-4889
10.1038/s41419-018-0573-2 doi
Angiotensin II Animals Collagen--metabolism Dipeptides--metabolism Disease Models, Animal Fibrosis GTP-Binding Proteins--antagonists & inhibitors Human Umbilical Vein Endothelial Cells--drug effects Humans Mice Myocardium--pathology Myofibroblasts--drug effects Protein Glutamine gamma Glutamyltransferase 2 Small Molecule Libraries--pharmacology Transforming Growth Factor beta1--pharmacology Transglutaminases--antagonists & inhibitors