TY - GEN AU - Zhuang,Gerald Z AU - Upadhyay,Udita AU - Tong,Xiaoying AU - Kang,Yuan AU - Erasso,Diana M AU - Fu,Eugene S AU - Sarantopoulos,Konstantinos D AU - Martin,Eden R AU - Wiltshire,Tim AU - Diatchenko,Luda AU - Smith,Shad B AU - Maixner,William AU - Levitt,Roy C TI - Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice SN - 1476-5462 PY - 2018///1105 KW - Analgesia KW - methods KW - Animals KW - Biomarkers, Tumor KW - biosynthesis KW - Dependovirus KW - genetics KW - Disease Models, Animal KW - Genetic Therapy KW - Humans KW - Hyperalgesia KW - Inositol 1,4,5-Trisphosphate Receptors KW - drug effects KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Nerve Growth Factor KW - antagonists & inhibitors KW - Neuralgia KW - Neurons KW - metabolism KW - Pain Management KW - Phosphorylation KW - Signal Transduction N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/s41434-018-0018-7 ER -