TY - GEN AU - Ruiz,Lucie AU - Gurlo,Tatyana AU - Ravier,Magalie A AU - Wojtusciszyn,Anne AU - Mathieu,Julia AU - Brown,Matthew R AU - Broca,Christophe AU - Bertrand,Gyslaine AU - Butler,Peter C AU - Matveyenko,Aleksey V AU - Dalle,Stéphane AU - Costes,Safia TI - Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment SN - 2041-4889 PY - 2019///1105 KW - Acetylation KW - Animals KW - Apoptosis KW - drug effects KW - Cytokines KW - metabolism KW - Diabetes Mellitus KW - enzymology KW - E1A-Associated p300 Protein KW - genetics KW - Glucose KW - toxicity KW - Histones KW - Humans KW - Inflammation Mediators KW - Insulin-Secreting Cells KW - Male KW - Melatonin KW - Mice, Inbred C57BL KW - Proteasome Endopeptidase Complex KW - Proteolysis KW - RNA, Messenger KW - Receptors, Melatonin KW - Signal Transduction N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/s41419-018-0603-0 ER -