TY  - GEN
AU  - Jennings,Laura E
AU  - Schiedel,Matthias
AU  - Hewings,David S
AU  - Picaud,Sarah
AU  - Laurin,Corentine M C
AU  - Bruno,Paul A
AU  - Bluck,Joseph P
AU  - Scorah,Amy R
AU  - See,Larissa
AU  - Reynolds,Jessica K
AU  - Moroglu,Mustafa
AU  - Mistry,Ishna N
AU  - Hicks,Amy
AU  - Guzanov,Pavel
AU  - Clayton,James
AU  - Evans,Charles N G
AU  - Stazi,Giulia
AU  - Biggin,Philip C
AU  - Mapp,Anna K
AU  - Hammond,Ester M
AU  - Humphreys,Philip G
AU  - Filippakopoulos,Panagis
AU  - Conway,Stuart J
TI  - BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
SN  - 1464-3391
PY  - 2018///1227
KW  - Biological Assay
KW  - Blotting, Western
KW  - Cell Cycle Proteins
KW  - Crystallography, X-Ray
KW  - Drug Stability
KW  - Heterocyclic Compounds, 4 or More Rings
KW  - chemistry
KW  - Humans
KW  - Inhibitory Concentration 50
KW  - Ligands
KW  - Luciferases
KW  - MCF-7 Cells
KW  - Molecular Dynamics Simulation
KW  - Molecular Structure
KW  - Nuclear Proteins
KW  - Structure-Activity Relationship
KW  - Transcription Factors
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.bmc.2018.05.003
ER  -