TY - GEN AU - Figueroa,Isabel AU - Leipold,Doug AU - Leong,Steve AU - Zheng,Bing AU - Triguero-Carrasco,Montserrat AU - Fourie-O'Donohue,Aimee AU - Kozak,Katherine R AU - Xu,Keyang AU - Schutten,Melissa AU - Wang,Hong AU - Polson,Andrew G AU - Kamath,Amrita V TI - Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an anti-CD33 ADC SN - 1942-0870 PY - 2019///0318 KW - Algorithms KW - Animals KW - Antibodies, Monoclonal KW - immunology KW - Cell Line, Tumor KW - HEK293 Cells KW - Humans KW - Immunoconjugates KW - Macaca fascicularis KW - Models, Biological KW - Prospective Studies KW - Sialic Acid Binding Ig-like Lectin 3 KW - Species Specificity N1 - Publication Type: Journal Article UR - https://doi.org/10.1080/19420862.2018.1465160 ER -