TY  - GEN
AU  - Speer,Esther M
AU  - Dowling,David J
AU  - Xu,Jianjin
AU  - Ozog,Lukasz S
AU  - Mathew,Jaime A
AU  - Chander,Avinash
AU  - Yin,Donglei
AU  - Levy,Ofer
TI  - Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro
SN  - 1932-6203
PY  - 2018///0801
KW  - Adolescent
KW  - Adult
KW  - Aging
KW  - blood
KW  - Anti-Inflammatory Agents
KW  - pharmacology
KW  - Azithromycin
KW  - Caspase 1
KW  - metabolism
KW  - Cytokines
KW  - biosynthesis
KW  - Dexamethasone
KW  - Drug Synergism
KW  - Dual Specificity Phosphatase 1
KW  - genetics
KW  - Enzyme Activation
KW  - drug effects
KW  - Female
KW  - Gene Expression Regulation
KW  - Humans
KW  - Infant, Newborn
KW  - Inflammasomes
KW  - Middle Aged
KW  - Mitogen-Activated Protein Kinases
KW  - Monocytes
KW  - NF-kappa B
KW  - Pentoxifylline
KW  - Pregnancy
KW  - RNA, Messenger
KW  - Signal Transduction
KW  - Toll-Like Receptors
KW  - Young Adult
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1371/journal.pone.0196352
ER  -