Speer, Esther M <br/><br/>
Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro.  [electronic resource] 

 -  PloS one  2018 
 - e0196352 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>1932-6203 
<br/><br/><label>Standard No.: </label>10.1371/journal.pone.0196352  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adolescent<br/>Adult<br/>Aging--blood<br/>Anti-Inflammatory Agents--pharmacology<br/>Azithromycin--pharmacology<br/>Caspase 1--metabolism<br/>Cytokines--biosynthesis<br/>Dexamethasone--pharmacology<br/>Drug Synergism<br/>Dual Specificity Phosphatase 1--genetics<br/>Enzyme Activation--drug effects<br/>Female<br/>Gene Expression Regulation--drug effects<br/>Humans<br/>Infant, Newborn<br/>Inflammasomes--metabolism<br/>Middle Aged<br/>Mitogen-Activated Protein Kinases--metabolism<br/>Monocytes--drug effects<br/>NF-kappa B--metabolism<br/>Pentoxifylline--pharmacology<br/>Pregnancy<br/>RNA, Messenger--genetics<br/>Signal Transduction--drug effects<br/>Toll-Like Receptors--metabolism<br/>Young Adult