Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling. [electronic resource]
- Drug metabolism and disposition: the biological fate of chemicals 07 2018
- 953-963 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1521-009X
10.1124/dmd.118.080614 doi
Adult Biological Transport--physiology Cell Line Cyclosporine--metabolism Drug Interactions--physiology Female HEK293 Cells Hepatocytes--drug effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors--metabolism Liver--drug effects Liver-Specific Organic Anion Transporter 1--metabolism Male Membrane Transport Proteins--metabolism Middle Aged Organic Anion Transporters, Sodium-Dependent--metabolism Quinolines--metabolism Rifampin--metabolism Solute Carrier Organic Anion Transporter Family Member 1B3--metabolism Symporters--metabolism