TY  - GEN
AU  - Roerink,Sophie F
AU  - Sasaki,Nobuo
AU  - Lee-Six,Henry
AU  - Young,Matthew D
AU  - Alexandrov,Ludmil B
AU  - Behjati,Sam
AU  - Mitchell,Thomas J
AU  - Grossmann,Sebastian
AU  - Lightfoot,Howard
AU  - Egan,David A
AU  - Pronk,Apollo
AU  - Smakman,Niels
AU  - van Gorp,Joost
AU  - Anderson,Elizabeth
AU  - Gamble,Stephen J
AU  - Alder,Chris
AU  - van de Wetering,Marc
AU  - Campbell,Peter J
AU  - Stratton,Michael R
AU  - Clevers,Hans
TI  - Intra-tumour diversification in colorectal cancer at the single-cell level
SN  - 1476-4687
PY  - 2018///0827
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Cell Proliferation
KW  - Clone Cells
KW  - drug effects
KW  - Colorectal Neoplasms
KW  - drug therapy
KW  - DNA Methylation
KW  - DNA Mutational Analysis
KW  - Evolution, Molecular
KW  - Gene Expression Regulation, Neoplastic
KW  - Humans
KW  - Intestinal Mucosa
KW  - metabolism
KW  - Intestines
KW  - cytology
KW  - Mutation
KW  - Mutation Rate
KW  - Organoids
KW  - Single-Cell Analysis
KW  - Transcriptome
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41586-018-0024-3
ER  -