Chen, Lu

Use of physiologically based kinetic modelling-facilitated reverse dosimetry to convert in vitro cytotoxicity data to predicted in vivo liver toxicity of lasiocarpine and riddelliine in rat. [electronic resource] - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Jun 2018 - 216-226 p. digital

Publication Type: Journal Article

1873-6351

10.1016/j.fct.2018.04.012 doi


Animals
Cells, Cultured
Dose-Response Relationship, Drug
Hepatocytes--drug effects
Liver--cytology
Male
Mice
Models, Biological
Pyrrolizidine Alkaloids--blood
Rats, Sprague-Dawley
Tissue Distribution
Toxicity Tests, Acute