Local, Andrea <br/><br/>
APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells.  [electronic resource] 

 -  Molecular cancer therapeutics  06 2018 
 - 1177-1186 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1538-8514 
<br/><br/><label>Standard No.: </label>10.1158/1535-7163.MCT-17-1209  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents--pharmacology<br/>Apoptosis--drug effects<br/>Cell Cycle Checkpoints--drug effects<br/>Cell Line, Tumor<br/>Cell Survival--drug effects<br/>Cyclin-Dependent Kinase Inhibitor p21--genetics<br/>DNA Damage--drug effects<br/>Dose-Response Relationship, Drug<br/>G-Quadruplexes--drug effects<br/>Gene Expression Regulation, Neoplastic--drug effects<br/>Humans<br/>Imidazoles--pharmacology<br/>Leukemia, Myeloid, Acute--genetics<br/>Phenanthrolines--pharmacology<br/>Proto-Oncogene Proteins c-myc--chemistry<br/>Signal Transduction--drug effects<br/>Stress, Physiological--drug effects