TY  - GEN
AU  - Chen,Shuliang
AU  - Bonifati,Serena
AU  - Qin,Zhihua
AU  - St Gelais,Corine
AU  - Kodigepalli,Karthik M
AU  - Barrett,Bradley S
AU  - Kim,Sun Hee
AU  - Antonucci,Jenna M
AU  - Ladner,Katherine J
AU  - Buzovetsky,Olga
AU  - Knecht,Kirsten M
AU  - Xiong,Yong
AU  - Yount,Jacob S
AU  - Guttridge,Denis C
AU  - Santiago,Mario L
AU  - Wu,Li
TI  - SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways
SN  - 1091-6490
PY  - 2018///0829
KW  - Animals
KW  - Cells, Cultured
KW  - Down-Regulation
KW  - Gene Expression Regulation
KW  - drug effects
KW  - Gene Silencing
KW  - HEK293 Cells
KW  - HIV
KW  - physiology
KW  - Humans
KW  - I-kappa B Kinase
KW  - antagonists & inhibitors
KW  - Immunity, Innate
KW  - Inflammation
KW  - immunology
KW  - Interferon Regulatory Factor-7
KW  - Interferon-alpha
KW  - biosynthesis
KW  - Macrophages
KW  - Male
KW  - Mice
KW  - NF-KappaB Inhibitor alpha
KW  - metabolism
KW  - NF-kappa B
KW  - Phosphorylation
KW  - Protein Processing, Post-Translational
KW  - Recombinant Proteins
KW  - SAM Domain and HD Domain-Containing Protein 1
KW  - Sendai virus
KW  - Signal Transduction
KW  - THP-1 Cells
KW  - Virus Diseases
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1073/pnas.1801213115
ER  -