TY - GEN AU - Van Heetvelde,Mattias AU - Van Bockstal,Mieke AU - Poppe,Bruce AU - Lambein,Kathleen AU - Rosseel,Toon AU - Atanesyan,Lilit AU - Deforce,Dieter AU - Van Den Berghe,Ivo AU - De Leeneer,Kim AU - Van Dorpe,Jo AU - Vral,Anne AU - Claes,Kathleen B M TI - Accurate detection and quantification of epigenetic and genetic second hits in BRCA1 and BRCA2-associated hereditary breast and ovarian cancer reveals multiple co-acting second hits SN - 1872-7980 PY - 2019///0611 KW - BRCA1 Protein KW - genetics KW - BRCA2 Protein KW - Cohort Studies KW - DNA Copy Number Variations KW - DNA Methylation KW - Epigenesis, Genetic KW - Female KW - Germ-Line Mutation KW - Hereditary Breast and Ovarian Cancer Syndrome KW - Humans KW - Loss of Heterozygosity KW - Models, Theoretical KW - Point Mutation KW - Promoter Regions, Genetic KW - Sequence Analysis, DNA KW - methods N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.canlet.2018.03.026 ER -