TY  - GEN
AU  - Poulin,Patrick
AU  - Haddad,Sami
TI  - Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mechanistic Insights
SN  - 1520-6017
PY  - 2019///0624
KW  - Albumins
KW  - metabolism
KW  - Anilino Naphthalenesulfonates
KW  - pharmacokinetics
KW  - Animals
KW  - Biological Transport
KW  - Fluorescent Dyes
KW  - Hepatocytes
KW  - Humans
KW  - Hydroxymethylglutaryl-CoA Reductase Inhibitors
KW  - Kinetics
KW  - Liver
KW  - Metabolic Clearance Rate
KW  - Models, Biological
KW  - Protein Binding
KW  - Quinolines
KW  - Rats
N1  - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.xphs.2018.03.012
ER  -