Poulin, Patrick <br/><br/>
Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mechanistic Insights.  [electronic resource] 

 -  Journal of pharmaceutical sciences  07 2018 
 - 1791-1797 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-6017 
<br/><br/><label>Standard No.: </label>10.1016/j.xphs.2018.03.012  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Albumins--metabolism<br/>Anilino Naphthalenesulfonates--pharmacokinetics<br/>Animals<br/>Biological Transport<br/>Fluorescent Dyes--pharmacokinetics<br/>Hepatocytes--metabolism<br/>Humans<br/>Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacokinetics<br/>Kinetics<br/>Liver--metabolism<br/>Metabolic Clearance Rate<br/>Models, Biological<br/>Protein Binding<br/>Quinolines--pharmacokinetics<br/>Rats