TY  - GEN
AU  - Rohde,Jason M
AU  - Brimacombe,Kyle R
AU  - Liu,Li
AU  - Pacold,Michael E
AU  - Yasgar,Adam
AU  - Cheff,Dorian M
AU  - Lee,Tobie D
AU  - Rai,Ganesha
AU  - Baljinnyam,Bolormaa
AU  - Li,Zhuyin
AU  - Simeonov,Anton
AU  - Hall,Matthew D
AU  - Shen,Min
AU  - Sabatini,David M
AU  - Boxer,Matthew B
TI  - Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors
SN  - 1464-3391
PY  - 2018///1005
KW  - Dose-Response Relationship, Drug
KW  - Drug Discovery
KW  - Enzyme Inhibitors
KW  - chemical synthesis
KW  - High-Throughput Screening Assays
KW  - Humans
KW  - Molecular Structure
KW  - Phosphoglycerate Dehydrogenase
KW  - antagonists & inhibitors
KW  - Piperazines
KW  - Structure-Activity Relationship
KW  - Thiourea
KW  - analogs & derivatives
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.bmc.2018.02.016
ER  -