TY - GEN AU - Xia,Pingping AU - Pan,Yundan AU - Zhang,Fan AU - Wang,Na AU - Wang,E AU - Guo,Qulian AU - Ye,Zhi TI - Pioglitazone Confers Neuroprotection Against Ischemia-Induced Pyroptosis due to its Inhibitory Effects on HMGB-1/RAGE and Rac1/ROS Pathway by Activating PPAR-ɤ SN - 1421-9778 PY - 2018///0619 KW - Animals KW - Astrocytes KW - drug effects KW - Cells, Cultured KW - Glucose KW - immunology KW - HMGB1 Protein KW - Infarction, Middle Cerebral Artery KW - drug therapy KW - Male KW - Neuroprotection KW - Neuroprotective Agents KW - therapeutic use KW - PPAR gamma KW - Pioglitazone KW - Pyroptosis KW - Rats, Sprague-Dawley KW - Reactive Oxygen Species KW - Receptor for Advanced Glycation End Products KW - Reperfusion Injury KW - Signal Transduction KW - Thiazolidinediones KW - rac1 GTP-Binding Protein N1 - Publication Type: Journal Article UR - https://doi.org/10.1159/000488183 ER -