UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells. [electronic resource]
- Cellular and molecular life sciences : CMLS Sep 2018
- 3393-3410 p. digital
Publication Type: Journal Article
1420-9071
10.1007/s00018-018-2799-7 doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--genetics Apoptosis--genetics Breast Neoplasms--metabolism Cell Proliferation Cholesterol--analysis Doxorubicin--pharmacology Drug Resistance, Neoplasm--genetics Female Glucosyltransferases--genetics Humans MCF-7 Cells Mitogen-Activated Protein Kinase 1--metabolism Mitogen-Activated Protein Kinase 3--metabolism Phosphatidylinositol 3-Kinases--metabolism Phosphoinositide-3 Kinase Inhibitors Protein Kinase C--antagonists & inhibitors Proto-Oncogene Proteins c-akt--metabolism Signal Transduction--genetics Sphingolipids--analysis Sphingomyelin Phosphodiesterase--genetics Sphingosine N-Acyltransferase--genetics