Wegner, Marthe-Susanna

UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells. [electronic resource] - Cellular and molecular life sciences : CMLS Sep 2018 - 3393-3410 p. digital

Publication Type: Journal Article

1420-9071

10.1007/s00018-018-2799-7 doi


ATP Binding Cassette Transporter, Subfamily B, Member 1--genetics
Apoptosis--genetics
Breast Neoplasms--metabolism
Cell Proliferation
Cholesterol--analysis
Doxorubicin--pharmacology
Drug Resistance, Neoplasm--genetics
Female
Glucosyltransferases--genetics
Humans
MCF-7 Cells
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3--metabolism
Phosphatidylinositol 3-Kinases--metabolism
Phosphoinositide-3 Kinase Inhibitors
Protein Kinase C--antagonists & inhibitors
Proto-Oncogene Proteins c-akt--metabolism
Signal Transduction--genetics
Sphingolipids--analysis
Sphingomyelin Phosphodiesterase--genetics
Sphingosine N-Acyltransferase--genetics