In Vitro Negative Inotropic Effect of Low Concentrations of Bupivacaine Relates to Diminished Ca2+ Sensitivity but Not to Ca2+ Handling or β-Adrenoceptor Signaling. [electronic resource]
- Anesthesiology 06 2018
- 1175-1186 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1528-1175
10.1097/ALN.0000000000002180 doi
Anesthetics, Local--administration & dosage Animals Bupivacaine--administration & dosage Calcium--metabolism Cells, Cultured Dose-Response Relationship, Drug Guinea Pigs Male Mice Myocardial Contraction--drug effects Myocytes, Cardiac--drug effects Organ Culture Techniques Receptors, Adrenergic, beta--physiology