Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates. [electronic resource]
- Cell death & disease 03 2018
- 407 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
2041-4889
10.1038/s41419-018-0441-0 doi
AMP-Activated Protein Kinase Kinases Amino Acid Motifs Aniline Compounds--pharmacology Animals Autophagy--drug effects Autophagy-Related Protein 7--genetics Autophagy-Related Protein-1 Homolog--genetics Cell Line Crotonates Hydroxybutyrates--pharmacology MAP Kinase Kinase Kinases--genetics Mice Nitriles Protein Aggregates--drug effects Protein Kinases--genetics Proteolysis--drug effects Ribosomal Protein S6 Kinases, 70-kDa--antagonists & inhibitors Superoxide Dismutase-1--genetics TOR Serine-Threonine Kinases--genetics Toluidines