GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one. [electronic resource]
- Nucleic acids research 05 2018
- 4022-4032 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1362-4962
10.1093/nar/gky143 doi
Cells, Cultured DNA Repeat Expansion Endonucleases--chemistry Exons Friedreich Ataxia--genetics Gene Knockdown Techniques HEK293 Cells Humans MutL Protein Homolog 1--metabolism MutL Proteins--chemistry Protein Domains Protein Isoforms--metabolism