Chen, Long <br/><br/>
Discovery of Novel KRAS-PDEδ Inhibitors by Fragment-Based Drug Design.  [electronic resource] 

 -  Journal of medicinal chemistry  03 2018 
 - 2604-2610 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.8b00057  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents--chemical synthesis<br/>Apoptosis--drug effects<br/>Cell Line<br/>Cyclic Nucleotide Phosphodiesterases, Type 6--antagonists & inhibitors<br/>Drug Design<br/>Drug Discovery<br/>Humans<br/>MAP Kinase Signaling System--drug effects<br/>Oncogene Protein v-akt--drug effects<br/>Peptide Fragments--chemistry<br/>Protein Binding<br/>Proto-Oncogene Proteins p21(ras)--chemical synthesis<br/>Reactive Oxygen Species--metabolism<br/>Structure-Activity Relationship