Dardaei, Leila <br/><br/>
SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors.  [electronic resource] 

 -  Nature medicine  05 2018 
 - 512-517 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1546-170X 
<br/><br/><label>Standard No.: </label>10.1038/nm.4497  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Anaplastic Lymphoma Kinase--antagonists & inhibitors<br/>Animals<br/>Carcinoma, Non-Small-Cell Lung--enzymology<br/>Cell Line, Tumor<br/>Drug Resistance, Neoplasm--drug effects<br/>Extracellular Signal-Regulated MAP Kinases--metabolism<br/>Female<br/>Gene Rearrangement--genetics<br/>Humans<br/>Lung Neoplasms--enzymology<br/>Mice, Nude<br/>Protein Kinase Inhibitors--pharmacology<br/>Protein Tyrosine Phosphatase, Non-Receptor Type 11--antagonists & inhibitors<br/>Pyrimidines--pharmacology<br/>RNA, Small Interfering--metabolism<br/>Sulfones--pharmacology