Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3. [electronic resource]
- BMC medical genomics 02 2018
- 12 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1755-8794
10.1186/s12920-018-0330-5 doi
Apoptosis Cell Proliferation Drug Resistance, Neoplasm Humans Imidazoles--pharmacology Lung Neoplasms--drug therapy Phosphatidylinositol 3-Kinases--genetics Piperazines--pharmacology Protein Kinase Inhibitors--pharmacology Signal Transduction TOR Serine-Threonine Kinases--genetics Tumor Cells, Cultured Tumor Suppressor Protein p53--genetics