Boyarskikh, Ulyana

Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3. [electronic resource] - BMC medical genomics 02 2018 - 12 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1755-8794

10.1186/s12920-018-0330-5 doi


Apoptosis
Cell Proliferation
Drug Resistance, Neoplasm
Humans
Imidazoles--pharmacology
Lung Neoplasms--drug therapy
Phosphatidylinositol 3-Kinases--genetics
Piperazines--pharmacology
Protein Kinase Inhibitors--pharmacology
Signal Transduction
TOR Serine-Threonine Kinases--genetics
Tumor Cells, Cultured
Tumor Suppressor Protein p53--genetics