TY  - GEN
AU  - Gerlach,Daniel
AU  - Tontsch-Grunt,Ulrike
AU  - Baum,Anke
AU  - Popow,Johannes
AU  - Scharn,Dirk
AU  - Hofmann,Marco H
AU  - Engelhardt,Harald
AU  - Kaya,Onur
AU  - Beck,Janina
AU  - Schweifer,Norbert
AU  - Gerstberger,Thomas
AU  - Zuber,Johannes
AU  - Savarese,Fabio
AU  - Kraut,Norbert
TI  - The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML
SN  - 1476-5594
PY  - 2019///0226
KW  - Animals
KW  - Antineoplastic Agents
KW  - administration & dosage
KW  - Cell Line, Tumor
KW  - Cell Survival
KW  - drug effects
KW  - Cyclin-Dependent Kinase 9
KW  - antagonists & inhibitors
KW  - Down-Regulation
KW  - Drug Synergism
KW  - Drug Therapy, Combination
KW  - Enhancer Elements, Genetic
KW  - Flavonoids
KW  - Gene Expression Profiling
KW  - methods
KW  - Gene Expression Regulation, Neoplastic
KW  - HL-60 Cells
KW  - Humans
KW  - Leukemia, Myeloid, Acute
KW  - drug therapy
KW  - Mice
KW  - Piperidines
KW  - Proteins
KW  - Pyrazines
KW  - RNA Polymerase II
KW  - metabolism
KW  - RNA-Binding Proteins
KW  - genetics
KW  - Transcription Factors
KW  - Triazoles
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41388-018-0150-2
ER  -