TY - GEN AU - Shen,Xiulong AU - Laber,Charles H AU - Sarkar,Ujjal AU - Galazzi,Fabio AU - Johnson,Kevin M AU - Mahieu,Nathaniel G AU - Hillebrand,Roman AU - Fuchs-Knotts,Tarra AU - Barnes,Charles L AU - Baker,Gary A AU - Gates,Kent S TI - Exploiting the Inherent Photophysical Properties of the Major Tirapazamine Metabolite in the Development of Profluorescent Substrates for Enzymes That Catalyze the Bioreductive Activation of Hypoxia-Selective Anticancer Prodrugs SN - 1520-6904 PY - 2018///0730 KW - Antineoplastic Agents KW - metabolism KW - Fluorescent Dyes KW - NADPH-Ferrihemoprotein Reductase KW - Oxidation-Reduction KW - Prodrugs KW - Tirapazamine KW - Triazines KW - Tumor Hypoxia KW - drug effects N1 - Publication Type: Journal Article UR - https://doi.org/10.1021/acs.joc.7b03035 ER -