TY  - GEN
AU  - Crawford,James J
AU  - Johnson,Adam R
AU  - Misner,Dinah L
AU  - Belmont,Lisa D
AU  - Castanedo,Georgette
AU  - Choy,Regina
AU  - Coraggio,Melis
AU  - Dong,Liming
AU  - Eigenbrot,Charles
AU  - Erickson,Rebecca
AU  - Ghilardi,Nico
AU  - Hau,Jonathan
AU  - Katewa,Arna
AU  - Kohli,Pawan Bir
AU  - Lee,Wendy
AU  - Lubach,Joseph W
AU  - McKenzie,Brent S
AU  - Ortwine,Daniel F
AU  - Schutt,Leah
AU  - Tay,Suzanne
AU  - Wei,BinQing
AU  - Reif,Karin
AU  - Liu,Lichuan
AU  - Wong,Harvey
AU  - Young,Wendy B
TI  - Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development
SN  - 1520-4804
PY  - 2019///0417
KW  - Agammaglobulinaemia Tyrosine Kinase
KW  - antagonists & inhibitors
KW  - Animals
KW  - Anti-Inflammatory Agents
KW  - pharmacokinetics
KW  - Arthritis, Experimental
KW  - drug therapy
KW  - Arthritis, Rheumatoid
KW  - Dogs
KW  - Drug Discovery
KW  - Humans
KW  - Lupus Erythematosus, Systemic
KW  - Madin Darby Canine Kidney Cells
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Piperazines
KW  - Protein Kinase Inhibitors
KW  - Pyridones
KW  - Rats
KW  - Rats, Inbred Lew
KW  - Rats, Sprague-Dawley
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/acs.jmedchem.7b01712
ER  -