Crawford, James J <br/><br/>
Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development.  [electronic resource] 

 -  Journal of medicinal chemistry  03 2018 
 - 2227-2245 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.7b01712  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Agammaglobulinaemia Tyrosine Kinase--antagonists & inhibitors<br/>Animals<br/>Anti-Inflammatory Agents--pharmacokinetics<br/>Arthritis, Experimental--drug therapy<br/>Arthritis, Rheumatoid--drug therapy<br/>Dogs<br/>Drug Discovery<br/>Humans<br/>Lupus Erythematosus, Systemic--drug therapy<br/>Madin Darby Canine Kidney Cells<br/>Models, Molecular<br/>Molecular Structure<br/>Piperazines--pharmacokinetics<br/>Protein Kinase Inhibitors--pharmacokinetics<br/>Pyridones--pharmacokinetics<br/>Rats<br/>Rats, Inbred Lew<br/>Rats, Sprague-Dawley