TY - GEN AU - Zhang,Ning AU - Zoltner,Martin AU - Leung,Ka-Fai AU - Scullion,Paul AU - Hutchinson,Sebastian AU - Del Pino,Ricardo C AU - Vincent,Isabel M AU - Zhang,Yong-Kang AU - Freund,Yvonne R AU - Alley,Michael R K AU - Jacobs,Robert T AU - Read,Kevin D AU - Barrett,Michael P AU - Horn,David AU - Field,Mark C TI - Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles SN - 1553-7374 PY - 2018///0622 KW - Activation, Metabolic KW - Aldehyde Dehydrogenase KW - antagonists & inhibitors KW - Aldehyde Oxidoreductases KW - Amine Oxidase (Copper-Containing) KW - Amino Acid Substitution KW - Animals KW - Boron Compounds KW - chemistry KW - Drug Resistance KW - High-Throughput Screening Assays KW - Humans KW - Models, Biological KW - Molecular Structure KW - Mutation KW - Phylogeny KW - Prodrugs KW - Protein Interaction Domains and Motifs KW - RNA Interference KW - Rats KW - Recombinant Fusion Proteins KW - Recombinant Proteins KW - Structure-Activity Relationship KW - Trypanocidal Agents KW - Trypanosoma brucei brucei KW - drug effects N1 - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1371/journal.ppat.1006850 ER -