Adams, Christopher M <br/><br/>
The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.  [electronic resource] 

 -  Journal of medicinal chemistry  02 2018 
 - 1622-1635 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.7b01731  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Topical<br/>Animals<br/>Choroidal Neovascularization<br/>Drug Discovery<br/>Indoles--administration & dosage<br/>Ophthalmic Solutions<br/>Protein Kinase Inhibitors<br/>Pyrazoles--administration & dosage<br/>Pyrimidines--administration & dosage<br/>Rabbits<br/>Rodentia<br/>Structure-Activity Relationship<br/>Vascular Endothelial Growth Factor Receptor-2--antagonists & inhibitors<br/>Wet Macular Degeneration--drug therapy