TY - GEN AU - Scheffel,Matthew J AU - Scurti,Gina AU - Wyatt,Megan M AU - Garrett-Mayer,Elizabeth AU - Paulos,Chrystal M AU - Nishimura,Michael I AU - Voelkel-Johnson,Christina TI - N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner SN - 1432-0851 PY - 2019///0228 KW - Acetylcysteine KW - pharmacology KW - Animals KW - Cells, Cultured KW - Forkhead Box Protein O1 KW - metabolism KW - Free Radical Scavengers KW - Gene Expression Regulation, Neoplastic KW - drug effects KW - Humans KW - Immunotherapy, Adoptive KW - Lymphocyte Activation KW - Melanoma KW - drug therapy KW - Mice KW - Phosphatidylinositol 3-Kinases KW - Proto-Oncogene Proteins c-akt KW - Signal Transduction KW - T-Lymphocytes, Cytotoxic KW - immunology N1 - Publication Type: Journal Article UR - https://doi.org/10.1007/s00262-018-2120-5 ER -