TY  - GEN
AU  - Jin,Bei
AU  - Wang,Chengyan
AU  - Shen,Yingying
AU  - Pan,Jingxuan
TI  - Anthelmintic niclosamide suppresses transcription of BCR-ABL fusion oncogene via disabling Sp1 and induces apoptosis in imatinib-resistant CML cells harboring T315I mutant
SN  - 2041-4889
PY  - 2019///0617
KW  - Animals
KW  - Anthelmintics
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Cell Proliferation
KW  - Down-Regulation
KW  - Drug Resistance, Neoplasm
KW  - Fusion Proteins, bcr-abl
KW  - genetics
KW  - Imatinib Mesylate
KW  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive
KW  - Mice, Nude
KW  - Mitochondria
KW  - Mitogen-Activated Protein Kinase Kinases
KW  - antagonists & inhibitors
KW  - Models, Biological
KW  - Mutation
KW  - Myeloid Cell Leukemia Sequence 1 Protein
KW  - metabolism
KW  - Niclosamide
KW  - Protein Kinase Inhibitors
KW  - Signal Transduction
KW  - Sp1 Transcription Factor
KW  - Survival Analysis
KW  - Transcription, Genetic
KW  - X-Linked Inhibitor of Apoptosis Protein
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41419-017-0075-7
ER  -