Jin, Bei <br/><br/>
Anthelmintic niclosamide suppresses transcription of BCR-ABL fusion oncogene via disabling Sp1 and induces apoptosis in imatinib-resistant CML cells harboring T315I mutant.  [electronic resource] 

 -  Cell death & disease  01 2018 
 - 68 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>2041-4889 
<br/><br/><label>Standard No.: </label>10.1038/s41419-017-0075-7  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Anthelmintics--pharmacology<br/>Apoptosis--drug effects<br/>Cell Proliferation--drug effects<br/>Down-Regulation--drug effects<br/>Drug Resistance, Neoplasm--drug effects<br/>Fusion Proteins, bcr-abl--genetics<br/>Imatinib Mesylate--pharmacology<br/>Leukemia, Myelogenous, Chronic, BCR-ABL Positive--genetics<br/>Mice, Nude<br/>Mitochondria--drug effects<br/>Mitogen-Activated Protein Kinase Kinases--antagonists & inhibitors<br/>Models, Biological<br/>Mutation--genetics<br/>Myeloid Cell Leukemia Sequence 1 Protein--metabolism<br/>Niclosamide--pharmacology<br/>Protein Kinase Inhibitors--pharmacology<br/>Signal Transduction--drug effects<br/>Sp1 Transcription Factor--metabolism<br/>Survival Analysis<br/>Transcription, Genetic--drug effects<br/>X-Linked Inhibitor of Apoptosis Protein--metabolism<br/>Xenograft Model Antitumor Assays