TY  - GEN
AU  - Krishnan,Navasona
AU  - Bonham,Christopher A
AU  - Rus,Ioana A
AU  - Shrestha,Om Kumar
AU  - Gauss,Carla M
AU  - Haque,Aftabul
AU  - Tocilj,Ante
AU  - Joshua-Tor,Leemor
AU  - Tonks,Nicholas K
TI  - Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development
SN  - 2041-1723
PY  - 2018///0222
KW  - Amino Acid Sequence
KW  - Anti-Obesity Agents
KW  - chemistry
KW  - Benzophenanthridines
KW  - Binding Sites
KW  - Cloning, Molecular
KW  - Crystallography, X-Ray
KW  - Enzyme Inhibitors
KW  - Escherichia coli
KW  - genetics
KW  - Gene Expression
KW  - Humans
KW  - Hypoglycemic Agents
KW  - Insulin
KW  - Isoquinolines
KW  - Leptin
KW  - Levamisole
KW  - Molecular Docking Simulation
KW  - Oxidation-Reduction
KW  - Protein Binding
KW  - Protein Interaction Domains and Motifs
KW  - Protein Structure, Secondary
KW  - Protein Tyrosine Phosphatase, Non-Receptor Type 1
KW  - antagonists & inhibitors
KW  - Recombinant Proteins
KW  - Single-Chain Antibodies
KW  - Small Molecule Libraries
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41467-017-02252-2
ER  -