TY - GEN AU - Verma,Ravi Kumar AU - Abramyan,Ara M AU - Michino,Mayako AU - Free,R Benjamin AU - Sibley,David R AU - Javitch,Jonathan A AU - Lane,J Robert AU - Shi,Lei TI - The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors SN - 1553-7358 PY - 2018///0618 KW - Allosteric Regulation KW - Allosteric Site KW - Bayes Theorem KW - Carboxylic Acids KW - Cluster Analysis KW - Computer Simulation KW - Humans KW - Hydrogen Bonding KW - Indoles KW - chemistry KW - Isoquinolines KW - Ligands KW - Markov Chains KW - Molecular Dynamics Simulation KW - Mutation KW - Phenotype KW - Protein Binding KW - Protein Domains KW - Protein Structure, Secondary KW - Receptors, Dopamine D2 KW - Receptors, Dopamine D3 KW - Structure-Activity Relationship N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1371/journal.pcbi.1005948 ER -