TY - GEN AU - Purohit,Hitesh S AU - Trasi,Niraj S AU - Sun,Dajun D AU - Chow,Edwin C Y AU - Wen,Hong AU - Zhang,Xinyuan AU - Gao,Yi AU - Taylor,Lynne S TI - Investigating the Impact of Drug Crystallinity in Amorphous Tacrolimus Capsules on Pharmacokinetics and Bioequivalence Using Discriminatory In Vitro Dissolution Testing and Physiologically Based Pharmacokinetic Modeling and Simulation SN - 1520-6017 PY - 2019///0408 KW - Capsules KW - Computer Simulation KW - Crystallization KW - Humans KW - Immunosuppressive Agents KW - administration & dosage KW - Models, Biological KW - Powder Diffraction KW - Solubility KW - Tacrolimus KW - Therapeutic Equivalency KW - X-Ray Diffraction N1 - Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1016/j.xphs.2017.12.024 ER -